MERP1 |
MERS-CoV ORF4b |
K252a |
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[Middle East respiratory syndrome coronavirus ORF4a] this open reading frame in the genome of MERS-CoV [Middle East respiratory syndrome coronavirus], the causative agent of severe-to-fatal pneumonia, encodes one of several viral accessory proteins. MERS-CoV ORF4a antagonises type 1 interferon responses by blocking pattern recognition receptor MDA-5 (Niemeyer et al, 2013; Yang et al, 2013). It interacts with PACT [protein activator of the interferon-induced protein kinase] in an dsRNA-dependent manner, inhibiting PACT-induced activation of RIG-I and MDA-5 but does not affect the activity of downstream effectors such as RIG-I, MDA-5, MAVS, TBK1, and IRF3
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