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MECIF

[monocyte-derived endothelial cell inhibitory factor] This biochemically uncharacterized factor has been isolated from non-activated monocytes (see also: cell activation) (Vilette et al, 1990). It inhibits the growth of human vascular endothelial cells and induces the expression of ELAM-1 (E-selectin, endothelium-leukocyte adhesion receptor 1) and significantly increases prostacyclin secretion.

MECIF activity appears to be immunologically distinct from IL1-beta (see: IL1), TNF-alpha, and TNF-beta.

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