MDDF |
Mdeiger |
alphaBC |
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[macrophage-derived endothelial cell inhibitor] This biochemically uncharacterized factor is secreted by human macrophages and isolated by heparin affinity chromatography (see also: HBGF). MD-ECI inhibits basal growth of endothelial cells and growth stimulated by FGF. Its effect on endothelial cells is dose-dependent, nontoxic, and reversible. MD-ECI is distinct from the known endothelial cell growth inhibitors such as TGF-beta and TNF-alpha (Besner and Klagsbrun, 1991).
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