MCTC mast cells |
MCT-COX2 |
cryptic peptides |
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[mitocryptide-COX1] This peptide, Formyl-MFADRWLFSTNHK, is a so-called mitocryptide (see also: cryptides). The peptide is derived from the N-terminus of the parent protein, which is MT-CO1 [mitochondrially encoded cytochrome c oxidase I], known also as Cytochrome c oxidase subunit 1, 1 of 3 subunits of respiratory Complex IV, the final enzyme of the electron transport chain of mitochondrial oxidative phosphorylation. The peptide potently activates the neutrophil NADPH oxidase to release superoxide and acts as an agonist for formyl peptide receptors FPR1 [formyl peptide receptor-1] or
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