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MCCP proliferation factor

[mast cell-committed progenitor proliferation factor] This biochemically uncharacterized factor (5 - 50 kDa) is found in the conditioned medium of fibroblasts. It allows late-stage murine progenitors committed to mast cells to form colonies in methylcellulose (see also: Colony formation assay).

When grown on monolayers of fibroblasts in the presence of this factor, progenitor cells committed to the lineage of mast cells can be obtained that are virtually uncontaminated with other hematopoietic progenitors (see also: hematopoiesis).

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