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Lymphoma growth factor

abbr. LGF (a term with multiple meanings). This biochemically uncharacterized factor has been found to be secreted into the conditioned medium by many different murine primary X-ray induced thymic lymphomas (PXTL) (Haas et al, 1986). It serves as an autocrine growth modulator for these cells. LGF dependent cells (see also: Factor-dependent cell lines) are non-tumorigenic or poorly tumorigenic and do not clone in soft agar. Upon progression PXTL cells become growth factor-independent, are highly tumorigenic in vivo and clone in soft agar.

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