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Lurcher mice

[Lurcher]

These mice (Phillips, 1960) carry a mutation in the GRID2 gene (symbol: Grid2Lc) (Zuo et al, 1997), a glutamate receptor subunit that has been identified as the receptor for cerebellin-1. Lurcher mice constitute a natural model of hereditary olivocerebellar degeneration, characterised by cerebellar ataxia and related motor changes (Porras-García et al, 2005; Hilber and Caston, 2001; Fortier et al, 1987; Cendelin et al, 2010). Semi-dominant heterozygous Lurcher mice suffer from progressive loss of cerebellar Purkinje cells, followed by the death of granule cells and inferior olive neurons ... ... ... ... ... Subscribe to continue reading! ... ...

 

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