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Leukocyte inhibitory factor

also: leukocyte migration inhibitory factor. Abbr. LIF (a term with multiple meanings). Leukocyte inhibitory factor inhibits the random and directed migration of polymorphonuclear (PMN) leukocytes. LIF also induces specific granule secretion by PMNs and potentiates many responses mediated by the chemotactic compound fMLP (formyl-methionyl-leucyl-phenylalanine) (see also: Chemotaxis). It activates human neutrophils and macrophages to release leukotriene B4 and thromboxanes.

LIF was purified initially from a human non-T, non-B-leukemia cell line ... ... ... ... ... Subscribe to continue reading! ... ...

 

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