Leishmania S3a-related protein
abbr. LmS3a-related protein, LmS3arp. This protein of 30 kKa is expressed by all Leishmania species so far examined (L. infantum, L. amazonensis, and L. mexicana). It is homologous to mammalian ribosomal protein S3a. Injection of the recombinant protein into BALB/c mice induces preferential cell activation of B-cells, causing increased expression of CD69 on IgM secreting spleen cells, a considerable increase of IgM-secreting B-cells, and elevated levels of serum IgM antibodies. These IgM antibodies are not specific to Leishmania antigens but preferentially recognize heterologous antigens such as myosin, thyroglobulin, DNA
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