Lactogen-like |
lactoglobulin-beta |
EH domain |
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This peptide with the sequence LIVTQTMKG is a bioactive fragment of Beta-lactoglobulin obtained by enzymatic digestion. It corresponds to Beta-lactoglobulin(1-9) (lactoglobulin-beta(1-9)). The peptide suppresses ghrelin secretion from MGN3-1 cells (ghrelin-secreting mouse ghrelinoma 3-1 from mouse stomach). Lacto-ghrestatin decreases intracellular cAMP levels and mRNA expression levels of ghrelin production-related genes in MGN3-1 cells. Orally administered lacto-ghrestatin decreases plasma ghrelin levels and food intake in fasted mice.
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