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LEAP cells

LEAP is an acronym that stands for Large cells that display Episodic release of Amidated Peptides. This term, coined by Park et al (2008) refers to a set of approximately 306 cells in the central nervous system of Drosophila melanogaster larvae. Amidated peptides are important neuromodulators / neurohormones in insects. Amidation is a specific and critical post-translational modification displayed by the vast majority (90 %) of Drosophila neuropeptides (Hewes et al, 2001; Eipper et al, 1992). In mammals, about 50 % of neuropeptides are amidated (Eipper et al, 1992).

LEAP cells are defined as neurosecretory neurons, and most of them express the bHLH transcription factor DIMMED (but not all peptidergic ... ... ... ... ... Subscribe to continue reading! ... ...

 

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