LEAP-2(38-47) |
Lebein |
A19 amacrine cells |
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LEAP is an acronym that stands for Large cells that display Episodic release of Amidated Peptides. This term, coined by Park et al (2008) refers to a set of approximately 306 cells in the central nervous system of Drosophila melanogaster larvae. Amidated peptides are important neuromodulators / neurohormones in insects. Amidation is a specific and critical post-translational modification displayed by the vast majority (90 %) of Drosophila neuropeptides (Hewes et al, 2001; Eipper et al, 1992). In mammals, about 50 % of neuropeptides are amidated (Eipper et al, 1992).
LEAP cells are defined as neurosecretory neurons, and most of them express the bHLH transcription factor DIMMED (but not all peptidergic
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