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LATI

[lymphokine-activated tumor inhibition] This is an experimental variant of the lymphokine mediated immunotherapy of tumors (see also: Adoptive immunotherapy) involving the use of LAK cells (lymphokine-activated killer cells).

This approach essentially involves local injections of low doses of IL2 into the tumor mass to induce non-reactive lymphocytes accumulated in the tumor mass to develop into reactive cells. A similar activation of cells has been observed also with the local injection of IL4 and immunoreactive peptide fragments of IL1.

Experimentally LATI has been successful in the treatment of poorly immunoreactive tumors.

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