LAP(+) CD4(+) T-cells

This cell type constitutes a distinct subpopulation of regulatory T-cells with an immunosuppressive function (Chen et al, 2008). The cells express TGF-beta-1 LAP peptide, the IL2 receptor IL2RA (CD25) and express elevated levels of transcription factor FOXP3, CTLA4, GITR, secrete TGF-beta, and express both cell surface TGF-beta and surface receptors for TGF-beta (Chen et al, 2008).

The cells have been shown to participate in the initiation and development of several autoimmune and inflammatory diseases (Duan et al, 2011; Ilan et al, 2010). Mahalingam et al (2012) have reported that these ... ... ... ...
 
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Entry last modified: May 2019