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KSHV orfK5

an open reading frame in the genome of KSHV (Kaposi sarcoma-associated herpesvirus). In BJAB-cells orfK5 protein dramatically reduces ICAM-1 (CD54) and B7-2 surface expression. B-cells engineered to express orfK5 protein show substantial impairment in their ability to induce cell activation of T-cells and this may be a way to reduce responses of T-cells to B-cells during the early phases of KSHV infection.

Thomas et al (2008) have reported that KSHV orfK5 protein reduces the cell surface expression of the NKG2D ligands MHC class I-related chain A (MICA), MICB, and the ligand for ... ... ... ... ... Subscribe to continue reading! ... ...

 

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