KSHV orfK4.2

[Kaposi sarcoma-associated herpesvirus orfK4.2]; also: KSHV K4.2 protein. Alternative designations: HHV-8 K4.2 protein [human herpesvirus type 8 K4.2 protein], HHV-8 orfK4.2 [human herpesvirus type 8 orfK4.2]. This protein is encoded by open reading frame K4.2 in the genome of KSHV (Kaposi sarcoma-associated herpesvirus). It has been shown to block immunoglobulin production (see: MZB1 [marginal zone B and B1 cell-specific protein]) and also appears to contribute to maximal lytic replication by enhancing viral glycoprotein expression levels and ultimately promoting the production of infectious virus (Wong LY et al, 2013).

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Entry last modified: April 2020