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KSHV LANA

[KSHV latency-associated nuclear antigen; Kaposi's sarcoma-associated herpes virus latency-associated nuclear antigen]; (HHV-8 LANA [HHV-8 latency-associated nuclear antigen 1]) also: KSHV LANA-1 [KSHV latency-associated nuclear antigen 1].

KSHV LANA is a virulence factor encoded by the KSHV ORF73 open reading frame. KSHV LANA is the most abundantly expressed protein during latency, is important for the long-term persistence of the viral episomal genome in dividing cells (Ballestas ME et al, 1999), and regulates multiple cellular pathways to promote virus replication and persistence (for overview see: Uppal et al, 2014). Barbera et al (2006) have reported that KSHV ... ... ... ... ... Subscribe to continue reading! ... ...

 

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