JC virus small t antigen

[JC virus tAg; abbr. JCV tAg] this antigen is encoded in the genome of JC polyomavirus, a DNA virus that is the causative agent of progressive multifocal leukoencephalopathy.

The protein has been reported to play a role in viral immune evasion. JC virus small t antigen functions as an interferon antagonist by suppressing signal transduction following activation of the nucleic acid sensor RIG-I.

The antigen interacts with the SPRY domain of E3 Ubiquitin Ligase TRIM25, thereby preventing its ability to bind RNA and to induce ubiquitination of RIG-I, which is required for RIG-I-mediated cytokine responses (Chiang C et al, 2021).

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Entry last modified: April 2022