iridophore |
Iridovirus caspase activation and recruitment domain protein |
Canal neuromasts |
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[Iridovirus caspase activation and recruitment domain protein] This protein, referred to also as vCARD [viral caspase activation and recruitment domain] is encoded in the genome of Grouper iridovirus, a virus belonging to the genus Ranavirus of the family Iridoviridae. The protein shows high similarity to other viral CARD genes and the human CARD-only protein, ICEBERG (CARD18).
Overexpression of the viral protein in HeLa cells inhibits cell death by apoptosis induced by mitochondrial and death receptor signaling. This is accompanied by a significant reduction of the activities of caspase-8 and caspase-9 following
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