IREM3 |
ir-FGF |
KRS1 |
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also known as Gefitinib. A chimaeric monoclonal human-mouse antibody (AstraZeneca), which inhibits the tyrosine kinase activity of the EGF receptor. Inhibition of receptor signaling in response to its ligands (EGF, TGF-alpha) blocks cell proliferation, enhances cell death by apoptosis, and interferes with tumor angiogenesis.
The antibody has been approved for the treatment of patients with advanced non-small-cell lung cancer in many countries and may be of utility in the treatment of other types of solid tumors (Herbst et al, 2004; D'Incecco and Cappuzzo, 2011).
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