IQKTPQIQVY |
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IL3-beta |
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(Ile-Gln-Trp) This tripeptide has been identified in a hydrolysate of egg white ovotransferrin obtained by treatment with thermolysin / pepsin (Majumder and Wu, 2011). The peptide is stable against digestive enzymes.
Majumder et al (2015) have reported antihypertensive effects of IQW in spontaneously hypertensive rats , showing that the peptide reduces plasma Angiontenin-2 levels and preserves nitric oxide dependent vasorelaxation. IQW also reduces the markers of inflammation (ICAM-1 expression) and oxidative/nitrosative stress.
Huang et al (2010) have reported that IQW inhibits increases of ICAM-1, VCAM-1, and CCL2 production induced in human
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