IIF-2
[tumor invasion-inhibiting factor-2; Invasion-inhibiting factor-2] This factor (AEDGDAKTDQAEKAEGAGDAK) is isolated from bovine liver (Isoai et al, 1990, 1992). It has a length of 21 amino acids and is identical with the carboxyterminal region (positions 69-89) of the DNA-binding non-histone protein HMGN2, and thus corresponds to HMGN2[69-89] or HMG17[69-89].
The factor suppresses the chemotactic migration of highly metastasizing B16 melanoma cells (see also: Chemotaxis) and inhibits the generation of lung metastases if it is injected at the same time as the tumor cells into mice.
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