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IFNgamma-MdC

[IFN-gamma-stimulated monocyte-derived cells] These cells constitute a distinct population of macrophages in a novel state of activation that mitigates colitis in mice. The cells are derived from mouse spleen, blood, and bone marrow monocytes and are distinguished from known macrophage populations by mode of generation, cell surface phenotype, and function. IFNgamma-MdC only arise when macrophages are cultivated in the presence of CD4(+) T-cells expressing CD40L, M-CSF, and IFN-gamma. They express markers including F4/80, CD11b/c, CD86, and CD274 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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