IFN-alpha(9-28) |
IFN-alpha II1 |
ADPEAF |
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This bioactive fragment (LYLTEKKYSPCAWEVVRAEIMRSLSLSTNLQERLRRKE) is derived from the C-terminus of human IFN-alpha and functions intracellularly as an IFN-mimetic (Ahmed and Johnson, 2014). For the purpose of gaining entry across the plasma membrane the sequence has been modified by attachment of a palmitic acid residue attached to the N-terminus.
The IFN-mimetic has been shown to inhibit melanoma cell proliferation in cell culture and also shows significant protection against lethal B16 melanoma in C57BL/6 mice. It is also a potent therapeutic against experimental allergic encephalomyelitis, a mouse model of multiple sclerosis but lacks the toxic side effects of the parent interferon
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