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IEX-1L

IEX-1L, found in databanks also under the submitted name Anti-death protein, protects cells from cell death by apoptosis induced by FAS antigen or TNF-alpha. IEX-1L is identical with IEX1 and encodes a protein that is longer than another form of the protein (IEX-1S). Transcription of the gene is induced by TNF and is decreased in cells with defective activation of transcription factor NF-kappa-B. Overexpression of antisense RNA against IEX-1L partially blocks TNF induced expression of IEX-1L and sensitizes normal cells ... ... ... ... ... Subscribe to continue reading! ... ...

 

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