IDWKKVDWKKVSKKTCKVMLKACKFLG |
IE2 |
GKLSGISKVLRAIAKFFKGVGKARKQFKEASDLDKNQ |
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[immediate early protein 1] This protein is encoded by open reading frame UL123 of human cytomegalovirus (Cytomegalovirus IE1 protein; Cytomegalovirus UL123 protein). This 72 kDa protein is being referred to in many publications also as IE1-72 or IE72 [Cytomegalovirus immediate early 72 protein]. It is involved in transcriptional regulation, controlling CMV early transcription (Gawn and Greaves, 2002). IE1 is an immediate-early gene product that is conditionally essential. Viruses lacking expression of IE1 replicate efficiently in fibroblasts
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