ICAD-S |
ICAM-1(+) neutrophils |
apoptosis-inducing TAF9-like domain 1 |
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[intercellular adhesion molecule 1] In the nomenclature of CD antigens this protein has been given the designation CD54.
ICAM-1 has been identified and named by Rothlein et al (1986) who showed that homotypic adhesion by phorbol ester-stimulated lymphocytes requires LFA-1 but does not involve like-like interactions between LFA-1 molecules on adjacent cells, which suggested the existence of a second molecule, distinct from LFA-1, that participates in LFA-1-dependent adhesion. They originally referred to the antigen as RR 1/1 antigen
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