IB-367 |
Ib-AMP |
Bbeta(15-42) |
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[ionized calcium binding adaptor molecule-1] This rat protein is an EF hand calcium binding protein. The gene is highly expressed in testis and spleen, but weakly in brain, lung, and kidney. In the brain the gene is expressed specifically in microglial cells. It is expressed in monoblastic cell lines but only very weakly expressed in myeloid cell lines. (Imai et al, 1996; Ito et al, 1998).
The protein has been shown to play a role in membrane ruffling and the phagocytosis of macrophages and microglial cells (Ohsawa et al, 2000).
The factor is identical with AIF-1 [Allograft inflammatory factor-1].
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