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Human respiratory syncytial virus SH protein

[Human respiratory syncytial virus small hydrophobic protein; HRSV SH protein; HRSV small hydrophobic protein] This small viral protein of 64 amino acids (antigenic subgroup A) or 65 amino acids (antigenic subgroup B) (Chen et al, 2000) is thought to act as a viroporin as it forms ion channels in membranes (Collins and Mottet 1993; Perez et al, 1997) and forms homo-oligomeric ion channel structures (Kochva et al, 2003). Gan et al (2012) have showm that SH protein forms pentameric oligomers that behave as ion channels when activated at low pH.

Triantafilou et al (2013) have reported that Human respiratory syncytial virus SH protein activates the NLRP3 inflammasome, suggesting that formation of viral ion channels in lipid bilayers of cells is a viral recognition pathway used by the host to signal ... ... ... ... ... Subscribe to continue reading! ... ...


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