Hsp20(71-91) |
HSPA1A |
chondrogenic progenitor cells |
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This fragment of heat shock protein hsp27, DRWRVSLDVNHFAPDELTVK, shows sequence homology to alpha-crystallins (Alpha-A-crystallin, Alpha-B-crystallin) (Nahomi et al, 2015). The peptide shows robust chaperone activity, inhibiting hyperthermic and chemically induced aggregation of client proteins. In HeLa cells, the peptide acts as a cell-penetrating peptide. HeLa cells take up a FITC-conjugated peptide, which is translocated from the cytoplasm to the nucleus when the cells are thermally stressed. The peptide also inhibits cell death by apoptosis in HeLa cells by blocking
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