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Hofbauer cells

[Hofbauer cell]

These cells are found in the connective tissue core of the chorionic villi of the placenta (Demir and Erbengi, 1984; Schmidt, 1992; Takahashi et al, 1991; Jones and Fox, 1991; Castellucci and Zaccheo, 1989; King, 1987; Castellucci et al, 1980; Wood, 1980; Kaufmann et al, 1977). Hofbauer cells often lie adjacent to a thick basement membrane, which underlies a layer of cytotrophoblast stem cells that are the progenitors of all the trophoblast lineages. They are the major cell type of the human placental villous core and are particularly numerous at the beginning of pregnancy. They are present in the villous core of the placenta from the early stage of pregnancy until full term (Castellucci et al, 1980).

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