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Herpesvirus saimiri BCL2

The protein encoded by orf16 of the oncogenic herpesvirus saimiri and mammalian BCL2 are homologous (Nava et al, 1997). The protein contains the BH1 and BH2 BCL2 homology domains and heterodimerizes with BCL2 family members BAX and BAK.

Expression of the viral protein protects cells from apoptosis mediated by a variety of apoptotic stimuli and appears to stabilize mitochondria (Derfuss et al, 1998). The viral protein has been shown to block the cleavage of PARP1 [poly(ADP-ribose) polymerase 1], a natural substrate of caspases resembling ... ... ... ... ... Subscribe to continue reading! ... ...


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