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Hepatitis C virus NS4A protein

[HCV NS4A protein] This protein (54 amino-acids) is a virus-encoded non-structural single-pass transmembrane protein that serves as an essential co-factor for the virus-encoded NS3 protein, a protein with serine protease and RNA helicase activities. It is essential for viral replication and particle assembly. NS4A together with NS3 protein are required for proteolytic processing of HCV nonstructural proteins from the polyprotein precursor (Failla et al, 1994; Tanji et al, 1995)

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