Hepatitis C virus E2 protein

abbr. HCV E2 protein; HCV glycoprotein E2] This glycoprotein is a virulence factor encoded in the genome of Hepatitis C virus. It is part of the viral envelope and also participates in immune evasion (see also: immunoevasins). E2 protein binds the human cell surface molecule CD81 with high affinity (Pileri et al, 1998).

Ligation of CD81 with E2 protein has been shown to costimulate T-cells. Binding of E2 protein lowers the threshold for IL2 receptor-alpha expression and IL2 production, resulting in strongly increased T-cell proliferation. E2 protein-induced co-stimulation also enhances the production of ... ... ... ...
 
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Entry last modified: July 2015