helix-turn-helix motif |
helmet cells |
acidic peptide AP(9-27) |
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[Hello Kitty mouse]
[Cpa3-Cre; Mcl-1fl/fl mice] These mice have been generated by crossing transgenic mice expressing Cre recombinase under the control of a promoter fragment from the carboxypeptidase A3 (Cpa3), which is expressed at very high levels only in the mast cell lineage, with mice in which the gene coding the anti-apoptotic factor MCL1 [myeloid cell leukemia sequence 1] (Lilla et al, 2011). These mice show a marked constitutive reduction in numbers of mast cells (92-100 % reduction in all anatomical sites tested except the spleen), which is independent of the functions of Kit
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