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Helicobacter Cytolethal distending toxin

This toxin is produced by various Helicobacter isolates and various other bacterial species (see: CDT). The toxin is cytolethal for HeLa cells and causes progressive cell distention and cytotoxicity. This is a three-component toxin that induces the irreversible arrest of the mammalian cell cycle in the G2 phase, and ultimately causes cell death by apoptosis. Because the factor can interfere with the cell cycle it can be grouped among the cyclomodulins.

For other relevant entries see also the Pathogenicity/Virulence Factors Dictionary section of this encyclopedia.

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Entry last modified: September 2003

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