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Heart derived inhibitor of vascular cell proliferation

This inhibitor of 11 kDa was isolated from whole bovine heart extracts (Westernacher and Schaper, 1995). It reversibly suppresses incorporation of tritiated thymidine into nuclei of bovine aortic endothelial cells and smooth muscle cells. The protein shows no homology to any hitherto structurally investigated growth inhibitors and cytokines. In databanks a short internal sequence has been published under vascular cell proliferation inhibitor (Accession: AAB47055.1)

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