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HKB-1

This cell line has been established from pulmonary Hodgkin disease of nodular sclerosing subtype of a 14-year-old girl. The cells have a B-cell phenotype and are also CD15(+), CD25(+) and CD30(+). The cells are not transformed by Epstein-Barr virus. The cells are pseudodiploid and show complex clonal structural aberrations. HKB-1 secrete high amounts of IL6 into the conditioned medium but do not secrete IL1-beta, IL2, IL4, IL10, IL12 or IFN-gamma (Wagner et al, 1998).

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