HIV1 gp41(638-673) |
HIV-1 matrix protein p17 |
BC-2 |
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This biochemically uncharacterized factor is secreted by CD8(+) T-cells after cell activation. It blocks HIV1 replication in naturally infected CD4(+) T-cells.
The factor is not identical with IFN-alpha-2, which also inhibits HIV1 replication. It is also not identical with IFN-beta, IFN-gamma, or TNF-alpha, which do not possess blocking activity. See also: CAF (CD8 cell antiviral factor).
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