HIV1 Rev protein |
HIV1 TAR RNA-binding protein B |
mitochondrial antiviral signaling protein |
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HIV1 Rev protein is a virus-encoded RNA-binding phosphoprotein of 116 amino acids that can shuttle between the nucleus and plays a central role both in the export of unspliced mRNAs. The interactions between Rev protein and viral RNAs requires the interaction of a 17-mer arginine-rich peptide region with Rev response elements on the RNA. The arginine-rich amino-terminal domain of Rev also serves as a signal for nuclear localization (for overview of Rev function see: Rausch and Le Grice, 2015).
HIV1 Rev(34-50) (also simply Rev peptide) (TRQARRNRRRRWRERQR) has been identified as a cell-penetrating peptide (Futaki et al, 2001, 2003). It shows very similar translocation characteristics to HIV1 Tat(48-60) (Suzuki et al, 2002).
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