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HIV1 Rev protein

This protein encoded in the HIV1 genome is a transactivator phosphoprotein that mediates the translocation of viral mRNAs from the nucleus to the cytoplasm. It is essential for shuttling viral mRNAs from the nucleus to the cytoplasm and essential for the expression of viral structural proteins (Malim et al, 1990; Elfgang C et al, 1999).

A specific Rev binding protein has been identified as the eukaryotic translation initiation factor EIF5A (Ruhl et al, 1993). Loss-of-function mutants of EIF5A block the nuclear export of Rev protein and HIV-1 replication (Bevec et al, 1996). Likewise, inhibition of the posttranslational incorporation of the rare amino acid Hypusine into EIF5A also blocks viral replication (Hoque et al, 2009; Schroeder et al, 2014; for overview see also: Olsen ME and Connor, 2017).

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