HIV-1 Rev(34-50)

HIV-1 Rev protein is a virus-encoded RNA-binding phosphoprotein of 116 amino acids that can shuttle between the nucleus and plays a central role both in the export of unspliced mRNAs. The interactions between Rev protein and viral RNAs requires the interaction of a 17-mer arginine-rich peptide region with Rev response elements on the RNA. The arginine-rich amino-terminal domain of Rev also serves as a signal for nuclear localization (for overview of Rev function see: Rausch and Le Grice, 2015).

HIV-1 Rev(34-50) (also simply Rev peptide) (TRQARRNRRRRWRERQR; Thr-Arg-Gln-Ala-Arg-Arg-Asn-Arg-Arg-Arg-Arg-Trp-Arg-Glu-Arg-Gln-Arg) has been identified as a cell-penetrating peptide ... ... ... ...
 
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Entry last modified: September 2017