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HGF/NK2

a truncated isoform of HGF (hepatocyte growth factor = scatter factor) composed of the amino terminus and first and second kringle domain (Lokker and Godowski, 1993).

NK2 is a naturally occurring splice variant of HGF that also acts through the HGF receptor, met. Otsuka et al (2000) have reported that NK2 antagonizes growth but facilitates metastasis. Transgenic mice broadly expressing NK2 exhibit none of the phenotypes characteristic of HGF/SF or NK1 transgenic mice. Coexpression of NK2 and HGF ... ... ... ... ... Subscribe to continue reading! ... ...

 

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