HGF/NK1
a naturally occurring truncated isoform of HGF (hepatocyte growth factor = scatter factor) composed of only the amino terminus and first kringle domain of the protein. NK1 acts as an antagonist of HGF in the absence of heparin. Heparan-sulfate proteoglycans have been shown to enhance binding of HGF-NK1 to the met receptor (Schwall et al, 1996).
The HGF/NK1 variant retains the ability to activate the Met receptor but is a weak agonist only (Jakubczak et al, 1998; Lokker and Godowski, 1993). Transgenic mice expressing NK1 have been shown to display most of the phenotypic characteristics associated with transgenic
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