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HGF/NK1

a naturally occurring truncated isoform of HGF (hepatocyte growth factor = scatter factor) composed of only the amino terminus and first kringle domain of the protein. NK1 acts as an antagonist of HGF in the absence of heparin. Heparan-sulfate proteoglycans have been shown to enhance binding of HGF-NK1 to the met receptor (Schwall et al, 1996).

The HGF/NK1 variant retains the ability to activate the Met receptor but is a weak agonist only (Jakubczak et al, 1998; Lokker and Godowski, 1993). Transgenic mice expressing NK1 have been shown to display most of the phenotypic characteristics associated with transgenic ... ... ... ... ... Subscribe to continue reading! ... ...

 

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