HepG2 |
HEP II |
Placental prolactin-like protein B |
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A biochemically poorly characterized factor of approximately 30 kDa found in the conditioned medium of the J774A.1 macrophage cell line and purified partially by its affinity towards heparin. HEP I is a heparin-binding growth factor different from IL1 and appears to contain activity resembling PDGF and inhibits the binding of labeled PDGF to its receptors, reacts with polyclonal anti-human PDGF antibody, and exhibits mitogenic activity for osteoblasts, which is partially blocked by anti-PDGF antisera. Like PDGF, HEP I is active in a wide variety of cell types, including osteoblasts, chondrocytes,
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