HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
Hedgehog |
cysteine-rich secretory protein LCCL domain containing 2 |
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[HECT domains]
[Homologous to the E6-AP Carboxyl Terminus] This domain of approximately 350 amino acids has been identified originally by sequence similarities to the C-terminal region of E6-AP, an E3 ubiquitin-protein liagse, which mediates thioester complex formation with ubiquitin (Schwarz et al, 1998; Huibregtse et al, 1995). The human genome encodes at least 20 different HECT domain proteins and this domain is thought to be the catalytic domain for the addition of ubiquitin to proteins. This modifies proteins and targets them for degradation by the ubiquitin-proteasome system, which regulates essential cellular processes such as cell cycle progression, signal transduction, DNA repair, and apoptosis
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