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H2009.1 peptide

This peptide with the sequence RGDLATLRQLAQEDGVVGVR has been identified by phage display methods aimed at finding peptide that preferentially binds to non-small cell lung cancer cell lines (lung adenocarcinoma cell line H2009) (Oyama et al, 2003; McGuire et al, 2014). The peptide acts as a cell-targeting peptide and has been shown also to home in to xenografted tumors in vivo and bind to patient tumor samples. This peptide binds to the restrictively expressed integrin, integrin-alpha-V / integrin-beta-6, which is upregulated in many human non-small-cell lung carcinomas compared to normal lung tissue (Elayadi et al, 2007).

Guthi et al (2010) have used this peptide ... ... ... ... ... Subscribe to continue reading! ... ...

 

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