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Growth inhibiting factor

abbr. GIF (a term with multiple meanings). This biochemically uncharacterized factor has been identified in conditioned medium of the neoplastic V79 Chinese hamster cell line based on its ability to inhibit the proliferation of the same cell line (Ichinose et al, 1993).

The partially purified activity reversibly inhibits the growth of a wide variety of human tumor cells, but not various normal human fibroblasts, in monolayer culture and in soft agar. GIF is not identical with TGF-beta, TNF-alpha, or IL1.

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