great alveolar cells |
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EPO mimetic peptide 1 |
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The term Greek key refers to the topological arrangement of beta-sheets in a protein in which several of these beta-sheets are connected by hairpins and oriented in an up-and-down antiparallel fashion. Such protein domains often form three-dimensional structures that are beta-barrels rather than beta-sandwiches and are found as structural units in the majority of beta-sandwich structures. The Greek key beta-barrel topology is a folding motif observed in many proteins of widespread evolutionary origin (Zhang and Kim, 2000; Hutchinson and Thornton, 1993). For an example see also: death fold.
For information on other protein domains and sequence motifs see also the Protein domains/sequence motifs Dictionary section of this encyclopedia.
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