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Granulocyte inhibitory protein

abbr. GIP (a term with multiple meanings). Two factors, GIP-1 (28 kDa) and GIP-2 (9.5 kDa), have been isolated from the serum filtrate of a patient with chronic kidney failure. GIP-1 is a member of the light chain family, and GIP-2 is the advanced glycosylation end product of Beta-2-Microglobulin.

GIP-1 inhibits glucose uptake, oxydative metabolism, Chemotaxis, and cytotoxic activity of segmented neutrophil granulocytes. GIP is probably one of the major contributors of the dysfunction of leukocytes frequently observed in uremic patients. GIP ... ... ... ... ... Subscribe to continue reading! ... ...


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