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Granularin

This protein of 81 amino acids is an internal defense peptide of the snail Lymnaea stagnalis, an intermediate hosts to schistosome parasites. Expression has been shown to increase in brain tissue upon infection with the avian schistosome Trichobilharzia ocellata. Granularin is secreted by granular cells in the connective tissue surrounding the brain. The purified protein acts as an opsonin that stimulates phagocytosis of foreign particles by blood hemocytes.

For other proteins/peptides with functions in innate immunity and/or antimicrobial activities see also: Innate immunity and defense peptides Dictionary.

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